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CPC 2018
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Curso de Atualização em Medicina Cardiovascular 2019
Reunião Anual Conjunta dos Grupos de Estudo de Cirurgia Cardíaca, Doenças Valvulares e Ecocardiografia da SPC
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0 Topics
A. Basics
B. Imaging
C. Arrhythmias and Device Therapy
D. Heart Failure
E. Coronary Artery Disease, Acute Coronary Syndromes, Acute Cardiac Care
F. Valvular, Myocardial, Pericardial, Pulmonary, Congenital Heart Disease
G. Aortic Disease, Peripheral Vascular Disease, Stroke
H. Interventional Cardiology and Cardiovascular Surgery
I. Hypertension
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L. Cardiovascular Pharmacology
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01. History of Cardiology
02. Clinical Skills
03. Imaging
04. Arrhythmias, General
05. Atrial Fibrillation
06. Supraventricular Tachycardia (non-AF)
07. Syncope and Bradycardia
08. Ventricular Arrhythmias and Sudden Cardiac Death (SCD)
09. Device Therapy
10. Chronic Heart Failure
11. Acute Heart Failure
12. Coronary Artery Disease (Chronic)
13. Acute Coronary Syndromes
14. Acute Cardiac Care
15. Valvular Heart Disease
16. Infective Endocarditis
17. Myocardial Disease
18. Pericardial Disease
19. Tumors of the Heart
20. Congenital Heart Disease and Pediatric Cardiology
21. Pulmonary Circulation, Pulmonary Embolism, Right Heart Failure
22. Aortic Disease
23. Peripheral Vascular and Cerebrovascular Disease
24. Stroke
25. Interventional Cardiology
26. Cardiovascular Surgery
27. Hypertension
28. Risk Factors and Prevention
29. Rehabilitation and Sports Cardiology
30. Cardiovascular Disease in Special Populations
31. Pharmacology and Pharmacotherapy
32. Cardiovascular Nursing
33. e-Cardiology / Digital Health
34. Public Health and Health Economics
35. Research Methodology
36. Basic Science
37. Miscellanea
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Long-term follow-up of patients with metabolic syndrome and coronary artery disease
Session:
Posters 5 - Écran 08 - Reabilitação Cardíaca
Speaker:
Ana Teresa Timóteo
Congress:
CPC 2018
Topic:
E. Coronary Artery Disease, Acute Coronary Syndromes, Acute Cardiac Care
Theme:
12. Coronary Artery Disease (Chronic)
Subtheme:
12.2 Coronary Artery Disease – Epidemiology, Prognosis, Outcome
Session Type:
Posters
FP Number:
---
Authors:
Ana Teresa Timóteo; Miguel Mota Carmo; cristina soares; Rui Cruz Ferreira
Abstract
<p>Background: Patients with obesity have an increased cardiovascular risk in primary prevention. In secondary prevention, many reports suggest an obesity paradox. Our objective was to study a cohort of patients that participated previously in a study about metabolic syndrome and atherosclerotic disease in a long-term follow-up.</p> <p>Methods: From a baseline cohort of 300 patients, 4 patients were lost to follow-up (final sample of 296 patients). All surviving patients in the follow-up had a mean follow-up of 6.9 ± 2.2 years. Patients were divided in 4 groups according to the presence of metabolic syndrome (MS) (AHA definition) and the presence of significant coronary artery disease (CAD) (stenosis ≥70%). The study end-points were all-cause mortality, cardiovascular mortality, cardiovascular re-admission and a combined endpoint (all-cause mortality, acute coronary syndrome, revascularization, stroke/transient ischemic attack, admission for heart failure).</p> <p>Results: The study population had a mean age of 65 ± 9 years, 59% males, 56% with MS and 41% with significant CAD. In the follow-up, we had 12.5% all-cause mortality, 4.7% cardiovascular mortality, 15.9% cardiovascular hospital admissions and 25.0% composite outcome. There was no significant difference in terms of all-cause mortality or cardiovascular mortality (Table). In patients without MS, cardiovascular re-admission and for the composite outcome was significantly higher in patients with CAD (Log-rank, p=0.001 and p=0.004, respectively) as well as in patients with MS (p=0.007 and p=0.002, respectively). In patients with CAD, there was a trend for higher all-cause mortality (Log-rank, p=0.284) and composite outcome (p=0.457) in the presence of MS but it did not reach statistical significance.</p> <p>Conclusions: In long-term follow-up, CAD had a significant impact in outcome, but not MS. These results question the impact of obesity and MS in secondary prevention, but larger samples are needed to confirm these results because the study might be underpowered.</p>
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