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BNP in patients with hypertrophic cardiomyopathy: results of the Portuguese registry
Session:
Posters 2 - Écran 09 - Miocárdio e Pericárdio
Speaker:
Elisabete Martins
Congress:
CPC 2018
Topic:
F. Valvular, Myocardial, Pericardial, Pulmonary, Congenital Heart Disease
Theme:
17. Myocardial Disease
Subtheme:
17.3 Myocardial Disease – Diagnostic Methods
Session Type:
Posters
FP Number:
---
Authors:
Elisabete Martins; Ana Margarida Lebreiro; Alexandra Sousa; Sérgio Machado Leite; Carla De Sousa; Adriana Belo; Em nome dos investigadores do Registo Nacional de Miocardiopatia Hipertrófica
Abstract
<p><strong>Introduction</strong></p> <p>In hypertrophic cardiomyopathy (HCM), plasma levels of B-type natriuretic peptide (BNP) have been associated with different parameters of left ventricle remodeling and clinical outcomes. A major issue is to understand if the occasional measurement of BNP in HCM is more dependent of the morpho-functional disease parameters (due to ongoing slow progressive disease mechanisms) or are mostly related with the acute condition of the patient (such as transient higher intraventricular pressure) at the time of blood collection.</p> <p><strong>Objective</strong></p> <p>In this study, we sought to determine if BNP measured in an occasional blood sample maintains any correlation with clinical parameters and if the associations are affected by the body mass index (BMI) in HCM patients.</p> <p><strong>Methods</strong></p> <p>We analyzed data from the National Registry of adults with HCM. All the included patients have BNP measurements, and the highest concentration of BNP was the value considered for the associations with clinical variables.</p> <p><strong>Results</strong></p> <p>Among 247 HCM patients, 57% males, 94% had asymmetrical LV hypertrophy, 38% intraventricular gradient, 16% moderate-severe mitral insufficiency, 68% symptoms at first consultation and 24% BMI >30. BNP correlated with age at diagnosis (r=0,300; p=0,000), left atrium diameter (r=0,292; p=0,000) and volume (r=0,353, P=0,003), septum (r=0,172; p=0,008) and posterior wall thickness (r=0,177; p=0,007) and the number of hypertrophied segments (r=0,303; p=0,009). BNP was negatively correlated with body surface area (r=-0,273; p=0,000) but not with BMI. BNP also didn´t correlate with intraventricular gradient.</p> <p><strong>Conclusion</strong></p> <p>Our results reinforce the usefulness of BNP measurement as a marker of LV remodeling in HCM, particularly the parameters related to LV hypertrophy and left atrium dilatation. BMI seems to not significantly affect these associations. </p>
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