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07. Syncope and Bradycardia
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akotsubo cardiomyopathy: predictors of early left ventricular systolic function recovery. A portuguese multicenter study
Session:
Posters 1 - Écran 10 - Miocárdio e Pericárdio
Speaker:
Liliana Rafaela Teles Reis
Congress:
CPC 2018
Topic:
F. Valvular, Myocardial, Pericardial, Pulmonary, Congenital Heart Disease
Theme:
17. Myocardial Disease
Subtheme:
17.2 Myocardial Disease – Epidemiology, Prognosis, Outcome
Session Type:
Posters
FP Number:
---
Authors:
Liliana Reis; João De Sousa Bispo; Bruno Marmelo; Ana Almeida; Margarida Oliveira; Rui Pontes Dos Santos; Maria João Matos Vieira; Catarina Ruivo; Ana Marreiros; Olga Azevedo
Abstract
<p>Introduction: Takotsubo cardiomyopathy (TC) is characterized by a transient left ventricular (LV) dysfunction. Wall motion abnormalities are generally transient and resolves within days to weeks, with a time to recovery very variable. Little is known about the factors that influence time to recovery of LV systolic function. <br /> <br /> Aim: Identify predictors of early LV systolic function recovery after hospital admission with TC. <br /> <br /> Methods: A Portuguese multicenter study involving 12 hospitals with inclusion of all patients diagnosed with TC in the last 11 years. Demographic, clinical, electrocardiographic and echocardiographic parameters were analyzed to found factors associated with early LV systolic function recovery (in the first 15 days after hospital admission). Multivariate analysis was performed to establish the independent predictors of early recovery of LV systolic function in patients with TC. <br /> <br /> Results: We included 238 patients with TC (mean age 66±12 years and 90% women). At hospital discharge, 15% of patients have complete recovery of LV systolic dysfunction and complete recovery had occurred in 37% of cases at 15 days after hospital admission. <br /> <br /> In patients with TC, the following factors are associated with LV systolic function recovery in the first 15 days after admission: <br /> <br /> Absence of chronic kidney disease (38% vs 0%, p=0.028), absence of previous report angina (40% vs 6.3%, p=0.080), absence of Q-waves in the initial ECG (40% vs 18%, p= 0,024) and absence of previous echocardiographic left ventricular wall motion abnormalities (75% vs 22%, p=0.036) were found to be associated with a higher probability of early LV ejection function recovery. In multivariate analyses, after adjusting for those variables, no independent predictor of early LV systolic function recovery was identified. <br /> <br /> Conclusions: Complete LV systolic function recovery in TC patients occurs in half of the cases up to 15 days after hospital admission. In this study, no independent predictor of LV function recovery in the first 15 days was identified, but other studies are needed to elucidate the importance of some of the risk factors identified.</p>
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