Login
Search
Search
0 Dates
2024
2023
2022
2021
2020
2019
2018
0 Events
CPC 2018
CPC 2019
Curso de Atualização em Medicina Cardiovascular 2019
Reunião Anual Conjunta dos Grupos de Estudo de Cirurgia Cardíaca, Doenças Valvulares e Ecocardiografia da SPC
CPC 2020
CPC 2021
CPC 2022
CPC 2023
CPC 2024
0 Topics
A. Basics
B. Imaging
C. Arrhythmias and Device Therapy
D. Heart Failure
E. Coronary Artery Disease, Acute Coronary Syndromes, Acute Cardiac Care
F. Valvular, Myocardial, Pericardial, Pulmonary, Congenital Heart Disease
G. Aortic Disease, Peripheral Vascular Disease, Stroke
H. Interventional Cardiology and Cardiovascular Surgery
I. Hypertension
J. Preventive Cardiology
K. Cardiovascular Disease In Special Populations
L. Cardiovascular Pharmacology
M. Cardiovascular Nursing
N. E-Cardiology / Digital Health, Public Health, Health Economics, Research Methodology
O. Basic Science
P. Other
0 Themes
01. History of Cardiology
02. Clinical Skills
03. Imaging
04. Arrhythmias, General
05. Atrial Fibrillation
06. Supraventricular Tachycardia (non-AF)
07. Syncope and Bradycardia
08. Ventricular Arrhythmias and Sudden Cardiac Death (SCD)
09. Device Therapy
10. Chronic Heart Failure
11. Acute Heart Failure
12. Coronary Artery Disease (Chronic)
13. Acute Coronary Syndromes
14. Acute Cardiac Care
15. Valvular Heart Disease
16. Infective Endocarditis
17. Myocardial Disease
18. Pericardial Disease
19. Tumors of the Heart
20. Congenital Heart Disease and Pediatric Cardiology
21. Pulmonary Circulation, Pulmonary Embolism, Right Heart Failure
22. Aortic Disease
23. Peripheral Vascular and Cerebrovascular Disease
24. Stroke
25. Interventional Cardiology
26. Cardiovascular Surgery
27. Hypertension
28. Risk Factors and Prevention
29. Rehabilitation and Sports Cardiology
30. Cardiovascular Disease in Special Populations
31. Pharmacology and Pharmacotherapy
32. Cardiovascular Nursing
33. e-Cardiology / Digital Health
34. Public Health and Health Economics
35. Research Methodology
36. Basic Science
37. Miscellanea
0 Resources
Abstract
Slides
Vídeo
Report
CLEAR FILTERS
Impact of anaemia on response and outcomes after cardiac resynchronization therapy
Session:
Posters 1 - Écran 01 - Arritmologia - Dispositivos
Speaker:
Rita Loreto Ilhão Moreira
Congress:
CPC 2018
Topic:
C. Arrhythmias and Device Therapy
Theme:
09. Device Therapy
Subtheme:
09.3 Cardiac Resynchronization Therapy
Session Type:
Posters
FP Number:
---
Authors:
Rita Ilhão Moreira; Ana Abreu; Tânia Branco Mano; João Pedro Reis; António Valentim Gonçalves; Tiago Mendonça; Madalena Coutinho Cruz; Dra. Inês Rodrigues; Luís Almeida Morais; Pedro Modas Daniel; Sílvia Aguiar Rosa; André Viveiros Monteiro; Guilherme Portugal; Pedro Silva Cunha; Mário Martins Oliveira; Rui Cruz Ferreira
Abstract
<p><strong>Background: </strong>Anaemia is a frequent comorbidity in heart failure patients and it is associated with worse outcomes. However, data evaluating the impact of anaemia on clinical outcome and response in patients with heart failure undergoing cardiac resynchronization therapy (CRT) is sparse.</p> <p><strong>Purpose: </strong>We sought to evaluate the ability of baseline haemoglobin (Hb) and change in Hb level over time to predict response and clinical outcome after CRT.</p> <p><strong>Methods: </strong>Prospective unicentric study which evaluated 114 consecutive pts who underwent CRT (69.23 ± 11.38 years; 68.1% male; 74.8% in class III of NYHA classification; 31.4% with ischemic cardiomyopathy; LV ejection fraction [LVEF] 26.03 ± 6.99%; 35% with atrial fibrillation, mean follow-up 25.5 ± 1.2.9 months). Hb was assessed prior and 6 month after CRT. Baseline anaemia was considered Hb <12 g/dL in women and <13 g/dL in men. CRT response was defined as ≥ 15% reduction in left ventricular endsystolic volume at 6 months after device implantation. The composite endpoint was all-cause mortality, cardiac transplant or heart failure hospitalization.</p> <p><strong>Results: </strong>Thirty-eight percent of the patients presented anaemia. Anaemic patients had lower estimated glomerular filtration rate (p 0.011), higher BNP levels (0.006) and presented more atrial fibrillation (p 0.018) and diabetes (p 0.038). Changes in left ventricular volumes, ejection fraction and peak oxygen consumption were similar for both groups. Anaemic patients had worse outcomes during follow-up when compared to their counterparts (log rank p 0.001). In multivariable Cox regression analysis, baseline Hb level remained an independent predictor of event-free survival after adjusting for other variables, including estimated glomerular filtration rate (HR 0.73, 95% CI 0.57-0.93, p 0.012). In anaemic patients, Hb level at 6 month follow up significantly increased in CRT responders (Hb at baseline 12.9 g/dL vs. Hb at follow-up 13.3 g/dL, p 0.049), while this was not evident in non-responders. Decreases in Hb of at least 1 g/dL were associated with worse outcomes in non-responder patients (log-rank p 0.047).</p> <p><strong>Conclusion: </strong>Baseline anaemia and decline in Hb levels are associated with a worse prognosis in CRT patients, even though the magnitude of left ventricular reverse remodelling is not influenced Significant increase in Hb levels at 6 months was only verified in CRT responders.</p>
Slides
Our mission: To reduce the burden of cardiovascular disease
Visit our site