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Is Lipoprotein(a) a predictor of computed tomography angiography findings? A retrospective study in a tertiary center
Session:
SESSÃO DE POSTERS 47 - AVALIAÇÃO CARDÍACA POR TC E/OU RM
Speaker:
Rui Miguel Gomes
Congress:
CPC 2025
Topic:
B. Imaging
Theme:
03. Imaging
Subtheme:
03.2 Computed Tomography
Session Type:
Cartazes
FP Number:
---
Authors:
Rui Miguel Gomes; C. Santos-Jorge; Ana Catarina Ribeiro; Claudia Silva; Francisco Gama; Pedro Lopes; Pedro Freitas; Sara Guerreiro; Pedro Araújo Gonçalves; João Abecassis; António Ferreira; Jorge Ferreira
Abstract
<p>Background: Lipoprotein(a) (Lp[a]) has emerged as a potential risk marker of atherosclerotic coronary artery disease (CAD). Previous studies have found mixed results with regards to the association of Lp(a) serum levels and coronary computed tomography angiography (CCTA) findings. The aim of this study is to evaluate the correlation between this genetically determined serum biomarker and CCTA findings. </p> <p>Methods: Data was collected from electronic medical records of patients who underwent CCTA in a single tertiary center. From these, patients who had a measurement of serum Lp(a) were selected. Clinical, laboratory and frequently evaluated CCTA finding as coronary artery calcium (CAC), CAD-reporting and data system 2 (CAD-RADS) and segment involvement score (SIS) were analyzed using Statistical Package for the Social Sciences, where a P value <0.05 was considered statistically significant. </p> <p>Results: 61 patients were selected, 74% male, with a mean age of 59±12 year. In this cohort no linear correlation was found between Lp(a) and SIS, CAD-RADs and CAC score. Furthermore, when categorized by terciles, Lp(a) had no statistically significant associations with these variables. When looking at high risk Lp(a) levels according to the 2022 European Society of Cardiology consensus statement (>250nmol/L), there was an association with a higher SIS (5 [1-8] vs. 16 [3-16], p= 0.01). However, there was no significant correlation with CAD-RADS (p=0.47) or CAC score (p=0.717). </p> <p>Conclusion: Lp(a) serum levels showed no significant linear correlation with commonly evaluated CCTA findings including SIS, CAD-RADS and CAC scores. When stratified according to high-risk Lp(a) levels (>250 nmol/L), there was a correlation with a higher SIS, suggesting a more diffuse coronary artery involvement, even without significant calcification or stenosis as assessed by CAD-RADS and CAC scores. Further studies with larger cohorts are needed to validate these observations.</p>
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